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Many forms of cutaneous and mucosal allergy are mediated for a large part by mast cells ; they play a central role in asthma , eczema , itch (from various causes) and allergic rhinitis and allergic conjunctivitis . Antihistamine drugs act by blocking the action of histamine on nerve endings. Cromoglicate -based drugs (sodium cromoglicate, nedocromil) block a calcium channel essential for mast cell degranulation, stabilizing the cell and preventing release of histamine and related mediators. Leukotriene antagonists (such as montelukast and zafirlukast ) block the action of leukotriene mediators, and are being used increasingly in allergic diseases.

Mast e mast

mast e mast

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